Our client is looking for a Associate Scientist to join its team.
The team is based both in Slough and Braine and is responsible for developing processes – scale up and piloting of the processes (cell-culture processes – focused on the upstream side of the process). One important aspect is harvesting – once the cells are grown in the bioreactor, and they get them to express the product, the team has to crude purification to remove cells from the product. The type of cells are CHO cells. Another aspect is understanding the scaleup and the transfer to the next scale of the manufacturing in the BPP biopilot (GMP facility).
In short, growing cells, developing the process, keeping them healthy and getting them to express the biologic molecule that is then purified and eventually reaches the patient.
Working with:
• Benchtop bioreactors systems, such as Amba systems, Sartorius,
• Larger scale piloting systems
• single-use bioreactors
• shake flasks,
• anything on which cell process can be run
What are the responsibilities?
The position is primarily lab-based:
– A mix of documentation.
– Preparing the protocol and the documents.
– Preparing the experimental designs and preparing the experiments.
– Making buffers
– Preparing meetings.
– Building bioreactor vessels
– Sterilizing equipment
– Running the bioreactor
– Keeping the cells nice and healthy throughout the whole process
– Monitoring, measuring, taking samples, recovering the product
– Doing harvest and clarification
– Working with colleagues from other departments.
Experience and Knowledge requirement
Must have
– Process development experience
– Knowledge of cell culture and bioreactor processes (any scale, pilot scale preferably)
– Experience with benchtop bioreactors systems, such as Amba systems, Sartorius, larger scale piloting systems, single-use bioreactors, shake flasks, aseptic techniques, etc.
– Minimum 2 years of experience
– Fully fluent in English, French is a nice to have
Nice to have
– Knowledge/experience with harvesting and clarifying processes – clarification, centrifugation, centrifuge operations, filtration
– Experience with antibody expression, recombinant protein expression
– GMP experience
Our offer?
Jefferson Wells offers you a permanent contract as a consultant with an attractive salary package and access to training in both technical and non-technical skills. We'll be your career partner every step of the way.
Are you interested in this position? We invite you to apply. Do you have any questions? Please contact Aylin Ugurlu at [email protected]
