Bioanalytical Scientist LC-MS
Contracting – Brabant Wallon
Your responsibilities:
The Precision Medecine (PM) Department is positioned within the function of Translational Science, a division which provides strategy and support to transition novel pharmacological assets, including small-molecule, biologics and gene therapy derived assets, from research into the clinic.
PM operate and collaborate closely across the organization to support bioanalysis and biomarker activities.
About the role:
We are seeking a self‑motivated, lab‑based scientist to support the development of LC‑MS pharmacokinetic assays that will advance our NCE and NBE assets. The lab works in close partnership with the relevant therapeutic area(s). The scientist will also play a pivotal role in transfer of assays into the regulated environment. The individual will also have an opportunity to take on project related responsibilities, executing on tailored bioanalytical strategies.
Who you’ll work with:
Development Bioanalysis is a team that sits within PM and are responsible for multiple key activities, supporting non-regulatory PK, Biodistribution & Immunogenicity assessments for NCE, NBE and Gene Therapy assets whilst also developing bioanalytical methods to support regulatory studies, transferring these methods into the Regulatory team for subsequent validation and testing.
You will operate in a matrix environment, collaborating with a wide range of internal stakeholders including Therapeutic Area project teams, Drug Metabolism and Pharmacokinetics, Non‑Clinical Safety and Quantitative Clinical Pharmacology.
What you’ll do:
- You will support the development and delivery of LC-MS PK assays and associated data sets for our small-molecule (NCE) and biologics (NBE) pipeline.
- Work within the bioanalytical teams to optimize experimental design, sample analysis, data interpretation and report generation.
Your profile:
- Candidates should have at least a BSc in a biological discipline with 1-3 years of hands-on experience in Bioanalysis.
- Experience with a range of analytical techniques supporting small‑ and large‑molecule bioanalysis, including enzymatic digestion approaches and immunocapture purification.
- Biological sample extraction and preparation techniques.
- Experience with cell-based and LBA assays is a plus.
- Proven track record of providing consistent routine high-quality bioanalytical support.
- Assay characterization and acceptance criteria, such as those required for progression of
- compounds into development.
- Continual bioanalytical method development and optimization.
- Trouble shooting of analytical and equipment issues to avoid delays in data generation.
- Good judgement to assess fit-for-purpose bioanalytical assay performance.
- Expert in LC-MS and other analytical tools, ideally Sciex and Waters LC-MS/MS.
- Excellent working knowledge of analytical software packages (Analyst, Sciex OS, Masslynx and Waters Connect).
- Demonstrated knowledge in using ELN (Watson, E-Workbook) and Microsoft Office